LPAR3 anticorps

N° du produit ABIN317691

Cet anticorps anti-LPAR3 est un anticorps Lapin Polyclonal détectant LPAR3 dans WB, IF et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour LPAR3 anticorps (ABIN317691)

Antigène: LPAR3 (Lysophosphatidic Acid Receptor 3 (LPAR3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-LPAR3 anticorps

Specificité: This antibody detects endogenous levels of EDG-7 protein (region surrounding Leu148).

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity-chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), 15 mM Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur LPAR3

Antigène: LPAR3 (Lysophosphatidic Acid Receptor 3 (LPAR3))

Autre désignation: EDG-7 / LPAR3

Sujet: The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain.Synonyms: EDG7, Endothelial differentiation, GPCR, HOFNH3O, LPA-3, LPAR3, Lysophosphatidic acid receptor 3, Lysophosphatidic acid receptor Edg-7, lysophosphatidic acid G-protein coupled receptor 7

Poids moléculaire: approx. 40 kDa

ID gène: 23566

NCBI Accession: NP_036284

UniProt: Q9UBY5

Pathways: Regulation of Cell Size