BDKRB1 anticorps

N° du produit ABIN317743

Cet anticorps Lapin Polyclonal détecte spécifiquement BDKRB1 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BDKRB1 anticorps (ABIN317743)

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BDKRB1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-BDKRB1 anticorps

Specificité: This antibody detects endogenous levels of Bradykinin B1 R protein.(region surrounding Arg239)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BDKRB1

Antigène: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Autre désignation: BDKRB1

Sujet: Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G protein-coupled receptors, named B1 and B2. The B2 receptor has an apparent molecular mass of 75-80 kDa (as observed in SDS-PAGE), is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.Synonyms: B1 bradykinin receptor, B1R, BK-1 receptor, BKB1R, BKR1, BRADYB1, Bradykinin B1 Receptor

Poids moléculaire: approx. 40 kDa

ID gène: 623

NCBI Accession: NP_000701

UniProt: P46663

Pathways: ACE Inhibitor Pathway