SUCNR1 anticorps

N° du produit ABIN317773

Cet anticorps Lapin Polyclonal détecte spécifiquement SUCNR1 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour SUCNR1 anticorps (ABIN317773)

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUCNR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-SUCNR1 anticorps

Specificité: This antibody detects endogenous levels of GPR91 protein.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SUCNR1

Antigène: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Autre désignation: Succinate Receptor 1 / GPR91

Sujet: GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.Synonyms: G-protein coupled receptor 91, P2Y purinoceptor 1-like

Poids moléculaire: approx. 38 kDa

ID gène: 56670

NCBI Accession: NP_149039

UniProt: Q9BXA5