AVPR1B anticorps

N° du produit ABIN317776

Cet anticorps Lapin Polyclonal détecte spécifiquement AVPR1B dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour AVPR1B anticorps (ABIN317776)

Antigène: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVPR1B est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AVPR1B anticorps

Specificité: AVP Receptor V3 antibody detects endogenous levels of AVP Receptor V3 protein.

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur AVPR1B

Antigène: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Autre désignation: Vasopressin V1b Receptor (V1bR)

Sujet: Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality. AVP mediates its effects through a family of G protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion. It is detected as an 85-90 kDa full length protein and a 46 kDa protein, which results from proteolytic cleavage of its amino terminus. The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration. The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.Synonyms: AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Avpr1b, Vasopressin V3 receptor

Poids moléculaire: approx. 47 kDa

ID gène: 553

NCBI Accession: NP_000698

UniProt: P47901

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones