CLCN4 anticorps

N° du produit ABIN317826

Détail du produit anti-CLCN4 anticorps

Antigène: CLCN4 (Chloride Channel 4 (CLCN4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLCN4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of CLC-4 protein.(region surrounding Glu254)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse and Rat.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 60000approx. 1: 80000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CLCN4

Antigène: CLCN4 (Chloride Channel 4 (CLCN4))

Autre désignation: CLCN4 (CLCN4 Produits)

Synonymes: anticorps Clc4-2, anticorps Clcn4, anticorps CLC4, anticorps ClC-4, anticorps ClC-4A, anticorps Clcn4-2, anticorps chloride voltage-gated channel 4, anticorps chloride channel, voltage-sensitive 4, anticorps CLCN4, anticorps clcn4, anticorps Clcn4

Sujet: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.Synonyms: CLC4, Chloride channel protein 4, Chloride transporter ClC-4, ClC-4, ClC4, H(+)/Cl(-) exchange transporter 4

Poids moléculaire: approx. 85 kDa

ID gène: 1183

NCBI Accession: NP_001821

UniProt: P51793