KCNJ9 anticorps

N° du produit ABIN317838

Détail du produit anti-KCNJ9 anticorps

Antigène: KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNJ9 est non-conjugé

Application: Western Blotting (WB)

Specificité: KIR3.3 antibody detects endogenous levels of KIR3.3 protein.(region surrounding Asp94)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KCNJ9

Antigène: KCNJ9 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9))

Autre désignation: KCNJ9 (KCNJ9 Produits)

Synonymes: anticorps GIRK3, anticorps KIR3.3, anticorps 1700085N21Rik, anticorps Girk3, anticorps Kir3.3, anticorps mbGIRK3, anticorps potassium voltage-gated channel subfamily J member 9, anticorps potassium inwardly-rectifying channel, subfamily J, member 9, anticorps KCNJ9, anticorps Kcnj9

Sujet: G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: G protein-activated inward rectifier potassium channel 3, GIRK3, Inwardly rectifier K(+) channel Kir3.3, KCNJ9, Potassium channel, inwardly rectifying subfamily J member 9

Poids moléculaire: approx. 44 kDa

ID gène: 3765

NCBI Accession: NP_004974

UniProt: Q92806