Six5 anticorps

N° du produit ABIN317916

Cet anticorps anti-Six5 Polyclonal Lapin (ABIN317916) détecte spécifiquement Six5 dans WB. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Six5 anticorps (ABIN317916)

Antigène: Six5 (SIX5) (Homeobox protein SIX5 (SIX5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Six5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Six5 anticorps

Specificité: Six5 antibody detects endogenous levels of Six5 protein.(region surrounding Leu237)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Six5

Antigène: Six5 (SIX5) (Homeobox protein SIX5 (SIX5))

Autre désignation: SIX5

Sujet: Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.Synonyms: DM locus-associated homeodomain protein, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5

Poids moléculaire: approx. 75 kDa

ID gène: 147912

NCBI Accession: NP_787071

UniProt: Q8N196