Six5 anticorps
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- Antigène Voir toutes Six5 (SIX5) Anticorps
- Six5 (SIX5) (Homeobox protein SIX5 (SIX5))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Six5 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Six5 antibody detects endogenous levels of Six5 protein.(region surrounding Leu237)
- Purification
- Affinity chromatography
- Top Product
- Discover our top product SIX5 Anticorps primaire
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- Indications d'application
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Six5 (SIX5) (Homeobox protein SIX5 (SIX5))
- Autre désignation
- SIX5 (SIX5 Produits)
- Synonymes
- anticorps Dmahp, anticorps MDMAHP, anticorps TrexBF, anticorps BOR2, anticorps DMAHP, anticorps sine oculis-related homeobox 5, anticorps SIX homeobox 5, anticorps Six5, anticorps SIX5
- Sujet
- Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye. Localized to the cytoplasm in early development and to the nucleus in the later stages of development,Six5 is involved in regulation of organogenesis and in maintenance of retinal formation. Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA. Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins. Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia. Two isoforms exist due to alternative splicing events.Synonyms: DM locus-associated homeodomain protein, DMAHP, Homeobox protein SIX5, Sine oculis homeobox homolog 5
- Poids moléculaire
- approx. 75 kDa
- ID gène
- 147912
- NCBI Accession
- NP_787071
- UniProt
- Q8N196
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