KCNK1
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
Biotin
Indications d'application
ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
KCNK1
(Potassium Channel Subfamily K Member 1 (KCNK1))
anticorps AI788889, anticorps TWIK-1, anticorps DPK, anticorps HOHO, anticorps K2P1, anticorps K2p1.1, anticorps KCNO1, anticorps TWIK1, anticorps Twik, anticorps k2p1.1, anticorps twik-1, anticorps twik1, anticorps rabKCNK1, anticorps im:7150627, anticorps kcnk1, anticorps zgc:165664, anticorps potassium channel, subfamily K, member 1, anticorps potassium two pore domain channel subfamily K member 1, anticorps potassium channel, two pore domain subfamily K, member 1 L homeolog, anticorps potassium channel, subfamily K, member 1a, anticorps Kcnk1, anticorps KCNK1, anticorps kcnk1.L, anticorps kcnk1a
Sujet
K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34 % homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.Synonyms: HOHO1, Inward rectifying potassium channel protein TWIK-1, KCNK1, KCNO1, Potassium channel KCNO1, Potassium channel subfamily K member 1, TWIK1