Collagen Type I anticorps

N° du produit ABIN318518

L’anticorps Lapin Polyclonal anti-Collagen Type I a été validé pour IHC (fro), IF et EIA. Il convient pour détecter Collagen Type I dans des échantillons de Humain et Porc.

Aperçu rapide pour Collagen Type I anticorps (ABIN318518)

Antigène: Collagen Type I (COL1) (Collagen, Type I (COL1))

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Collagen Type I est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-Collagen Type I anticorps

Specificité: This antibody reacts with native and heat denatured Porcine Collagen type 1 and 3. Less than 0.5 % reactivity is observed with Porcine Albumin and Immunoglobulins.

Réactivité croisée (Details): Also reacts to: type III

Purification: Purified

Immunogène: Porcine Collagen, types 1 and 3 from skin

Isotype: IgG

Information d'application

Indications d'application: Immunofluorescence: 1/10-1/40. ELISA: 1/500-1/2000. Immunohistochemistry on Frozen Sections: 1/10-1/40.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Restore the vial (50 μg) with 500 μL of sterile distilled water or saline.

Buffer: Mannitol, dextran and salts.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Détails sur Collagen Type I

Antigène: Collagen Type I (COL1) (Collagen, Type I (COL1))

Autre désignation: Collagen Type I

Sujet: Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations, these mutations alter splicing, often leading to the exclusion of multiple exons.Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2

ID gène: 1277

NCBI Accession: NP_000079

UniProt: P02452