BAG1 anticorps (C-Term)

N° du produit ABIN318738

Cet anticorps anti-BAG1 Polyclonal Lapin (ABIN318738) détecte spécifiquement BAG1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BAG1 anticorps (C-Term) (ABIN318738)

Antigène: BAG1 (BCL2-Associated Athanogene (BAG1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAG1 anticorps

Épitope: C-Term

Specificité: This antibody detects an epitope within the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1).

Purification: Purified

Immunogène: 14 amino acid peptide from near the carboxy terminus of human BAG1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1 - 2g/mL, detects a band of approximately 39 kDa in PC3 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BAG1

Antigène: BAG1 (BCL2-Associated Athanogene (BAG1))

Autre désignation: BAG1

Sujet: BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms, a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.Synonyms: BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46

ID gène: 573

NCBI Accession: NP_001165886

UniProt: Q99933