STXBP1 anticorps (pSer515)

N° du produit ABIN318802

Cet anticorps Lapin Polyclonal détecte spécifiquement STXBP1 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Singe, Boeuf (Vache), Chien, Poulet et Xenopus laevis.

Aperçu rapide pour STXBP1 anticorps (pSer515) (ABIN318802)

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reactivité: Humain, Souris, Rat, Singe, Boeuf (Vache), Chien, Poulet, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STXBP1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-STXBP1 anticorps

Épitope: pSer515

Specificité: This antibody recognises Munc-18 phosphorylated at serine 515.

Purification: Purified

Immunogène: Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1: 1000, detects a band/s of approximately 65 kDa in rat cortex cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM Hepes pH 7.5 containing 0.09 % Sodium Azide (NaN3), 50 % Glycerol and 0.01 % Bovine Serum Albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur STXBP1

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Autre désignation: STXBP1 / UNC18A

Sujet: Munc-18 is a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

ID gène: 25558

NCBI Accession: NP_037170

UniProt: P61765

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport