CCR5 anticorps (AA 6-20)
-
- Antigène Voir toutes CCR5 Anticorps
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
-
Épitope
- AA 6-20
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp CCR5 est non-conjugé
-
Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Specificité
- This antibody recognises the N-terminal region of the chemokine receptor CCR5, also known as CD195. CCR5 is a receptor for the beta chemokines RANTES, MIP-1alpha and MIP-1beta.
- Purification
- Purified
- Immunogène
- Peptide corresponding to amino acids 6 to 20 of human CCR5.
- Isotype
- IgG
- Top Product
- Discover our top product CCR5 Anticorps primaire
-
-
- Indications d'application
-
Western Blot: 1: 1000. Immunohistochemistry on paraffin sections: 20 μg/mL, This product requires antigenretrieval using heat treatment prior to staining of paraffin sections, Sodium citrate buffer pH 6.0 is recommended for this purpose.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate buffered saline containing 0.02 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Antigène
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
- Autre désignation
- CD195 / CCR5 (CCR5 Produits)
- Synonymes
- anticorps CC-CKR-5, anticorps CCCKR5, anticorps CCR-5, anticorps CD195, anticorps CKR-5, anticorps CKR5, anticorps CMKBR5, anticorps IDDM22, anticorps Ckr5, anticorps Cmkbr5, anticorps CCR1-L, anticorps GPCR, anticorps CCR5, anticorps AM4-7, anticorps C-C motif chemokine receptor 5 (gene/pseudogene), anticorps chemokine (C-C motif) receptor 5, anticorps C-C motif chemokine receptor 5, anticorps CCR5, anticorps Ccr5
- Sujet
- The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.Synonyms: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor
- ID gène
- 1234
- NCBI Accession
- NP_000570
- UniProt
- P51681
- Pathways
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
-