GFAP anticorps

N° du produit ABIN335275

Cet anticorps Lapin Polyclonal détecte spécifiquement GFAP dans WB, IHC, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Rat, Souris et Poisson zèbre (Danio rerio) et a été mentionné dans 2+ publications.

Aperçu rapide pour GFAP anticorps (ABIN335275)

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reactivité: Humain, Rat, Souris, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: K39

Détail du produit anti-GFAP anticorps

Specificité: Human, mouse and rat.

Purification: Antiserum

Immunogène: K39 is a rabbit polyclonal antiserum derived by immunization of a rabbit with a glial fibrillary acidic protein preparation from human spinal cord.

Information d'application

Indications d'application: K39 reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells. K39 is suitable for immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C

Références pour anticorps anti-GFAP (ABIN335275)

Herpers, Ramaekers, Aldeweireldt, Moesker, Slooff: "Co-expression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas." dans: Acta neuropathologica, Vol. 70, Issue 3-4, pp. 333-9, (1986) (PubMed).

Ramaekers, Puts, Moesker, Kant, Huysmans, Haag, Jap, Herman, Vooijs: "Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview." dans: The Histochemical journal, Vol. 15, Issue 7, pp. 691-713, (1983) (PubMed).

Détails sur GFAP

Antigène: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Autre désignation: Glial fibrillary acidic protein / GFAP

Sujet: GFAP (55 kD) is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer€™s disease, epilepsy and multiple sclerosis. In the peripheral nervous system GFAP is expressed by Schwann cells. Upon differentiation, myelin forming Schwann cells down-regulate GFAP, whereas in non-myelin forming Schwann cells GFAP persists into adulthood.