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CD56 anticorps

NCAM1 Reactivité: Humain, Poisson zèbre (Danio rerio) WB, IHC (p), IHC (fro), ICC Hôte: Souris Monoclonal 123C3 unconjugated
N° du produit ABIN335374
  • Antigène Voir toutes CD56 (NCAM1) Anticorps
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    Reactivité
    • 258
    • 72
    • 67
    • 26
    • 17
    • 14
    • 12
    • 10
    • 10
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    Humain, Poisson zèbre (Danio rerio)
    Hôte
    • 176
    • 89
    • 3
    • 1
    Souris
    Clonalité
    • 194
    • 74
    • 1
    Monoclonal
    Conjugué
    • 97
    • 15
    • 14
    • 13
    • 11
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD56 est non-conjugé
    Application
    • 166
    • 133
    • 59
    • 48
    • 48
    • 37
    • 32
    • 31
    • 27
    • 26
    • 15
    • 13
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Specificité
    Human.
    Purification
    Purified
    Immunogène
    123C3 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with the a membrane preparation of a small cell lung carcinoma specimen.
    Clone
    123C3
    Isotype
    IgG1
    Top Product
    Discover our top product NCAM1 Anticorps primaire
  • Indications d'application
    123C3 was defined as a cluster I antibody during the First International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. 123C3 recognizes an epitope in the NCAM exons 11-13 which is dependent on an intact conformation of the first fibronectin type-III homologous domain encoded by these exons. 123C3 stains NCAM which is present in small cell lung cancer and lung carcinoids. It also reacts with a number of non-small cell lung carcinomas and neuroendocrine and neuronal derived tissues. In addition, 123C3 is internalized after binding to its antigen on SCLC cell lines, making it an excellent reagent for tumor imaging in xenograft models. 123C3 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
    Restrictions
    For Research Use only
  • Stock
    4 °C
  • Kwa, Verheijen, Litvinov, Dijkman, Mooi, Van Krieken: "Prognostic factors in resected non-small cell lung cancer: an immunohistochemical study of 39 cases." dans: Lung cancer (Amsterdam, Netherlands), Vol. 16, Issue 1, pp. 35-45, (1997) (PubMed).

    Kwa, Verhoeven, Storm, van Zandwijk, Mooi, Hilkens: "Radioimmunotherapy of small-cell lung cancer xenografts using 131I-labelled anti-NCAM monoclonal antibody 123C3." dans: Cancer immunology, immunotherapy : CII, Vol. 41, Issue 3, pp. 169-74, (1995) (PubMed).

    Gerardy-Schahn, Eckhardt: "Hot spots of antigenicity in the neural cell adhesion molecule NCAM." dans: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 8, pp. 38-42, (1994) (PubMed).

    Kibbelaar, Moolenaar, Michalides, Van Bodegom, Vanderschueren, Wagenaar, Dingemans, Bitter-Suermann, Dalesio, Van Zandwijk: "Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma." dans: European journal of cancer (Oxford, England : 1990), Vol. 27, Issue 4, pp. 431-5, (1991) (PubMed).

    Moolenaar, Muller, Schol, Figdor, Bock, Bitter-Suermann, Michalides: "Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212." dans: Cancer research, Vol. 50, Issue 4, pp. 1102-6, (1990) (PubMed).

    Schol, Mooi, van der Gugten, Wagenaar, Hilgers: "Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues." dans: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 2, pp. 34-40, (1988) (PubMed).

    Mooi, Wagenaar, Schol, Hilgers: "Monoclonal antibody 123C3 in lung tumour classification. Immunohistology of 358 resected lung tumours." dans: Molecular and cellular probes, Vol. 2, Issue 1, pp. 31-7, (1988) (PubMed).

  • Antigène
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    Autre désignation
    NCAM / CD56 (NCAM1 Produits)
    Synonymes
    anticorps CD56, anticorps MSK39, anticorps NCAM, anticorps fj56g09, anticorps ncam, anticorps ncam1, anticorps wu:fj56g09, anticorps NCAM1, anticorps n-cam, anticorps E-NCAM, anticorps NCAM-1, anticorps Ncam, anticorps Cd56, anticorps N-CAM, anticorps N-CAM-1, anticorps NCAM-C, anticorps NCAMC, anticorps N-CAM-1-B, anticorps NCAM-1-B, anticorps ncam1-a, anticorps ncam1-b, anticorps neural cell adhesion molecule 1, anticorps neural cell adhesion molecule 1a, anticorps neural cell adhesion molecule 1 S homeolog, anticorps neural cell adhesion molecule 1 L homeolog, anticorps NCAM1, anticorps ncam1a, anticorps ncam1, anticorps LOC100085373, anticorps ncam1.S, anticorps Ncam1, anticorps ncam1.L
    Sujet
    NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
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