Fibronectin anticorps

N° du produit ABIN336929

L’anticorps anti-Fibronectin Polyclonal Lapin est utilisé pour la détection de Fibronectin dans des échantillons de Humain. Il a été validé pour IHC et IHC (p).

Aperçu rapide pour Fibronectin anticorps (ABIN336929)

Antigène: Fibronectin

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fibronectin est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Fibronectin anticorps

Specificité: This antibody reacts with human fibronectin in liver, tonsil, skin and kidney. Molecular Weight: Non reduced 400-440 kDa, reduced 200-220 kDa.

Immunogène: Purified human Fibronectin from human plasma

Information d'application

Indications d'application: Immunohistochemistry (IHC) 1:100-1:400 for 30 minute at room temp. using polymer system or streptavidin-biotin system. Formalin-fixed paraffin-embedded (FFPE) tissue sections and cell smears require antigen retriever, boiling tissue in 10 mM citrate buffer, pH 6.0 for 10-20 minute, followed by cooling at room temp. for 20 minutes. The optimum dilution should be determined by the individual lab. Positive Control: Human kidney. Cellular Localization: Connective tissue matrix and basement membrane.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Immunized serum in10 mM PO4, 150 mM NaCl, pH 7.4, 0.05% sodium azide. HostRabbit ReagentConc. antibody

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur Fibronectin

Antigène: Fibronectin

Sujet: Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and extracellular matrix. Fibronectin is involved in cell adhesion and migration process including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They also occur as dimmer of two 200 kDa subunits. Fibronectin has been implicated in carcinoma development in lung cancer. Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents.