Prosaposin anticorps

N° du produit ABIN347759

L’anticorps anti-Prosaposin Polyclonal Lapin est utilisé pour la détection de Prosaposin dans des échantillons de Humain. Il a été validé pour WB, ELISA et ICC.

Aperçu rapide pour Prosaposin anticorps (ABIN347759)

Antigène: Prosaposin (PSAP)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prosaposin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-Prosaposin anticorps

Specificité: Reacts with human Saposin-B

Réactivité croisée (Details): May cross react with proteins from other species due to sequence homology

Purification: Antiserum

Immunogène: Synthetic peptide derived from an internal domain of human PSAP

Isotype: IgG

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC1:200 - 1:1 000 WB1:500 - 1:5 000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Stock: 4 °C/-20 °C

Stockage commentaire: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Date de péremption: 24 months

Détails sur Prosaposin

Antigène: Prosaposin (PSAP)

Autre désignation: Proactivator Polypeptide Domain Saposin-B (PSAP)

Sujet: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator.

ID gène: 5660

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity