CHMP6 anticorps (C-Term)

N° du produit ABIN350231

L’anticorps Lapin Polyclonal anti-CHMP6 a été validé pour WB et IHC. Il convient pour détecter CHMP6 dans des échantillons de Souris.

Aperçu rapide pour CHMP6 anticorps (C-Term) (ABIN350231)

Antigène: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CHMP6 anticorps

Épitope: C-Term

Fonction: Rabbit antibody to CHMP6

Specificité: Specific for CHMP6.

Réactivité croisée: Souris, Rat

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from the c-terminal region of mouse CHMP6 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with rat's.

Isotype: IgG

Information d'application

Indications d'application: IHC WB. Use at a concentration of 10-50,micro,g,ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur CHMP6

Antigène: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Autre désignation: CHMP6

Sujet: FUNCTION: Component of the ESCRT-III complex which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex it probably serves as an acceptor for ESCRT-II complex on endosomal membranes. SUBUNIT: Component of the endosomal sorting required for transport complex III (ESCRT-III) at least composed of CHMP1A CHMP1B CHMP2A CHMP2B CHMP3/VPS24 CHMP4A/SHAX2 CHMP4B/SHAX1 CHMP4C/SHAX3 CHMP5/SNF7DC2 and CHMP6/VPS20. In the complex it interacts directly with CHMP4A CHMP4B and CHMP4C. Interacts directly with SNF8 VPS25 and VPS36 components of the ESCRT-II complex. SUBCELLULAR LOCATION: Intracytoplasmic membrane. Endosome membrane, Lipid-anchor . Note: Localizes to endosomal membranes.

UniProt: P0C0A3