VAMP7 anticorps

N° du produit ABIN351365

L’anticorps Lapin Polyclonal anti-VAMP7 a été validé pour WB et IHC. Il convient pour détecter VAMP7 dans des échantillons de Rat.

Aperçu rapide pour VAMP7 anticorps (ABIN351365)

Antigène: VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VAMP7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-VAMP7 anticorps

Fonction: Rabbit antibody to VAMP7

Specificité: Specific for VAMP7.

Réactivité croisée: Humain, Marmoset, Souris, Rat

Réactivité croisée (Details): Other species not yet tested.

Purification: IgG

Immunogène: A synthetic peptide from rat VAMP7 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.

Isotype: IgG

Information d'application

Indications d'application: IHC WB. A working concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur VAMP7

Antigène: VAMP7 (Vesicle-Associated Membrane Protein 7 (VAMP7))

Autre désignation: VAMP7

Sujet: FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. SUBUNIT: Component of the SNARE complex composed of STX4 SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7 STX8 VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells. SUBCELLULAR LOCATION: Cytoplasmic vesicle secretory vesicle membrane, Single-pass type IV membrane protein. Golgi apparatus trans-Golgi network membrane, Single-pass type IV membrane protein. Late endosome membrane, Single-pass type IV membrane protein. Lysosome membrane, Single-pass type IV membrane protein. Endoplasmic reticulum membrane, Single-pass type IV membrane protein. Cytoplasmic vesicle phagosome membrane, Single-pass type IV membrane protein. TISSUE SPECIFICITY: Detected in all tissues tested.

UniProt: Q9JHW5