CUL9 anticorps (C-Term)

N° du produit ABIN356104

Cet anticorps Lapin Polyclonal détecte spécifiquement CUL9 dans WB, IHC et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour CUL9 anticorps (C-Term) (ABIN356104)

Antigène: CUL9 (Cullin 9 (CUL9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CUL9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-CUL9 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: affinity purified

Immunogène: 17 amino acid synthetic peptide from near the carboxy terminus of human PARC.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Détails sur CUL9

Antigène: CUL9 (Cullin 9 (CUL9))

Autre désignation: PARC/P53-associated Parkin-like Cytoplasmic Protein

Sujet: PARC (p53 associated parkin like cytoplasmic protein) antibody directly interacted and formed an approximately 1MD complex with p53 in the cytoplasm of unstressed cells. In the absence of stress, inactivation of PARC induced nuclear localization of endogenous p53 and activated p53 dependent apoptosis. Overexpression of PARC promoted cytoplasmic sequestration of ectopic p53. Furthermore, abnormal cytoplasmic localization of p53 was observed in a number of neuroblastoma cell lines, RNA interference-mediated reduction of endogenous PARC significantly sensitized these neuroblastoma cells in the DNA damage response. These results revealed that PARC is a critical regulator in controlling p53 subcellular localization and subsequent function.