SETD8 anticorps (N-Term)

N° du produit ABIN356374

Cet anticorps Souris Monoclonal détecte spécifiquement SETD8 dans WB et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour SETD8 anticorps (N-Term) (ABIN356374)

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SETD8 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 43AT551-86

Détail du produit anti-SETD8 anticorps

Épitope: N-Term

Specificité: This antibody is specific SET07.

Attributs du produit: Synonyms: SET8, PRSET7, PR-Set7, KMT5A, Histone-lysine N-methyltransferase SETD8, H4-K20-HMTaseSETD8, SET domain-containing protein 8, PR/SET domain-containing protein 07, LysineN-methyltransferase 5A

Purification: Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This antibody was raised using purified recombinant GST fusion protein encoding theN-terminal region of human SET07.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur SETD8

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Autre désignation: SETD8 / SET07

Sujet: SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.Synonyms: H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, KMT5A, Lysine N-methyltransferase 5A, PR-Set7, PR/SET domain-containing protein 07, PRSET7, SET domain-containing protein 8, SET8

ID gène: 387893

UniProt: Q9NQR1