SETD8 anticorps (C-Term)

N° du produit ABIN356688

Cet anticorps anti-SETD8 est un anticorps Lapin Polyclonal détectant SETD8 dans WB et EIA. Adapté pour Humain.

Aperçu rapide pour SETD8 anticorps (C-Term) (ABIN356688)

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD8 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-SETD8 anticorps

Épitope: AA 364-393, C-Term

Specificité: This antibody is specific to Human SETD8 / SET07 (C-term)

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: KLH conjugated synthetic peptide between 364~393 amino acids from the C-terminal region of human SET07

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur SETD8

Antigène: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Autre désignation: SETD8 / SET07

Sujet: SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.Synonyms: H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, KMT5A, Lysine N-methyltransferase 5A, PR-Set7, PR/SET domain-containing protein 07, PRSET7, SET domain-containing protein 8, SET8

ID gène: 387893, 9606

UniProt: Q9NQR1