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Deoxyguanosine Kinase anticorps (C-Term)

DGUOK Reactivité: Humain, Souris WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN359186
  • Antigène Voir toutes Deoxyguanosine Kinase (DGUOK) Anticorps
    Deoxyguanosine Kinase (DGUOK)
    Épitope
    • 10
    • 9
    • 7
    • 7
    • 5
    • 1
    • 1
    C-Term
    Reactivité
    • 41
    • 11
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 39
    • 2
    Lapin
    Clonalité
    • 39
    • 2
    Polyclonal
    Conjugué
    • 17
    • 6
    • 5
    • 5
    • 4
    • 4
    Cet anticorp Deoxyguanosine Kinase est non-conjugé
    Application
    • 34
    • 34
    • 4
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to Deoxyguanosine Kinase (DGUOK).
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGUOK.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DGUOK Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    Deoxyguanosine Kinase (DGUOK)
    Autre désignation
    Deoxyguanosine Kinase (DGUOK Produits)
    Synonymes
    anticorps DGUOK, anticorps zgc:86625, anticorps dgk, anticorps DDBDRAFT_0218264, anticorps DDBDRAFT_0233982, anticorps DDB_0218264, anticorps DDB_0233982, anticorps MTDPS3, anticorps dGK, anticorps dGK1, anticorps dGK2, anticorps dGK3, anticorps deoxyguanosine kinase, anticorps deoxyguanosine kinase L homeolog, anticorps DGUOK, anticorps dguok, anticorps dguok.L, anticorps dgk, anticorps Ccan_04750, anticorps Dguok
    Sujet
    Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.Synonyms: DGK, DGUOK
    ID gène
    1716, 9606
    UniProt
    Q16854
    Pathways
    Ribonucleoside Biosynthetic Process
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