TWSG1 anticorps

N° du produit ABIN360945

Cet anticorps anti-TWSG1 est un anticorps Rat Monoclonal détectant TWSG1 dans WB et IHC (fro). Adapté pour Souris.

Aperçu rapide pour TWSG1 anticorps (ABIN360945)

Antigène: TWSG1 (Twisted Gastrulation Homolog 1 (TWSG1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp TWSG1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 7D19

Détail du produit anti-TWSG1 anticorps

Specificité: This antibody detects Mouse TSG. Other species not tested.

Purification: Protein A/G Affinity Chromatography

Immunogène: Purified Mouse Recombinant TSG

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry on frozen sections: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μL/mL.

Buffer: PBS, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TWSG1

Antigène: TWSG1 (Twisted Gastrulation Homolog 1 (TWSG1))

Autre désignation: TWSG1 / Tsg

Sujet: Twisted gastrulation (TSG) is a secreted, cysteine-rich protein that plays a role in dorsal/ventral patterning in Drosophila and Xenopus by regulating BMP signaling. TSG was originally identified in Drosophila melanogaster and shown to be required for the differentiation of the dorsal amnioserosa cells. Studies of expression and function of Twisted Gastrulation have been performed in Drosophila and Xenopus. Xenopus TSG is expressed in the ventral regions of the embryo during gastrulation, mimicking the BMP-4 expression pattern. TSG is expressed in dorsal cells of the blastoderm embryo, where there are also high levels of activity of Dpp and Screw. Vertebrate TSGs were subsequently cloned in mouse, human, zebrafish and frog. TSG acts as an agonist for BMP signaling by modulating the inhibitory actions of the BMP antagonist, Chordin/Sog, and the cleavage properties of the metalloprotease, xolloid/tolloid. The N-terminal domain of TSG can bind BMP protein directly in vitro and shows BMP antagonist activity.Synonyms: Twisted gastrulation protein homolog 1

ID gène: 65960

NCBI Accession: NP_075540

UniProt: Q9EP52