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PNPLA3 anticorps (Internal Region)

Verified PNPLA3 Reactivité: Humain, Souris WB, ELISA, IHC Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN361184
  • Antigène Voir toutes PNPLA3 Anticorps
    PNPLA3 (Patatin-Like phospholipase Domain Containing 3 (PNPLA3))
    Épitope
    • 15
    • 11
    • 9
    • 9
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Internal Region
    Reactivité
    • 39
    • 36
    • 3
    • 1
    Humain, Souris
    Hôte
    • 67
    • 3
    • 2
    Chèvre
    Clonalité
    • 72
    Polyclonal
    Conjugué
    • 30
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PNPLA3 est non-conjugé
    Application
    • 60
    • 37
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Fonction
    Pnpla3 / Adiponutrin (mouse)
    Séquence
    EHDICPKVKS TN
    Specificité
    This antibody is raised against a peptide derived from the Mouse protein sequence and this peptide differs from Human only in position 2.
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
    Classe de qualité
    Verified
    Immunogène
    Peptide with sequence EHDICPKVKSTN, from the internal region of the protein sequence according to NP_473429.2.
    Isotype
    IgG
  • Indications d'application

    Immunohistochemistry: Paraffin embedded Human Kidney. Recommended concentration: 8 μg/mL.

    Western Blot: Approx 45 kDa band observed in Mouse Adrenal Gland lysates, and also in preliminary testing of Mouse and Human Kidney and Rat Adrenal Gland lysate (calculated MW of 42.6Da according to Mouse NP_473429.2). Recommended concentration: 0.01-0.03

    Peptide ELISA: antibody detection limit dilution 1:16000.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Minimize freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.
  • Yang, Mottillo, Mladenovic-Lucas, Zhou, Granneman: "Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes." dans: Nature metabolism, Vol. 1, Issue 5, pp. 560-569, (2019) (PubMed).

    Hao, Ito, Huang, Sae-tan, Lambert, Ross: "Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells." dans: Metabolism: clinical and experimental, Vol. 63, Issue 10, pp. 1352-62, (2014) (PubMed).

    Kumari, Schoiswohl, Chitraju, Paar, Cornaciu, Rangrez, Wongsiriroj, Nagy, Ivanova, Scott, Knittelfelder, Rechberger, Birner-Gruenberger, Eder, Brown, Haemmerle, Oberer, Lass, Kershaw, Zimmermann et al.: "Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. ..." dans: Cell metabolism, Vol. 15, Issue 5, pp. 691-702, (2012) (PubMed).

    Gustavsson, Soga, Wahlström, Vesterlund, Azimi, Norstedt, Tollet-Egnell: "Sex-dependent hepatic transcripts and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats." dans: Journal of molecular endocrinology, Vol. 47, Issue 2, pp. 129-43, (2011) (PubMed).

  • Antigène
    PNPLA3 (Patatin-Like phospholipase Domain Containing 3 (PNPLA3))
    Autre désignation
    Pnpla3 (PNPLA3 Produits)
    Synonymes
    anticorps ADPN, anticorps C22orf20, anticorps iPLA(2)epsilon, anticorps Adpn, anticorps patatin like phospholipase domain containing 3, anticorps patatin-like phospholipase domain containing 3, anticorps PNPLA3, anticorps Pnpla3
    Sujet
    Pnpla3, patatin-like phospholipase domain containing 3, Adpn, adiponutrin
    Poids moléculaire
    42.6kDa
    ID gène
    80339, 116939, 362972
    NCBI Accession
    NP_473429
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