ABCA4 anticorps

N° du produit ABIN361347

Détail du produit anti-ABCA4 anticorps

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivité: Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABCA4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for ABCA4

Réactivité croisée: Boeuf (Vache), Humain, Souris, Xenopus laevis

Purification: Protein G purified culture supernatant

Immunogène: Partially purified bovine 220-kDa disc rim protein

Clone: 3F4

Isotype: IgG

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur ABCA4

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Autre désignation: ABCA4 (ABCA4 Produits)

Synonymes: anticorps ABC10, anticorps ABCR, anticorps ARMD2, anticorps CORD3, anticorps FFM, anticorps RMP, anticorps RP19, anticorps STGD, anticorps STGD1, anticorps AW050280, anticorps Abc10, anticorps Abcr, anticorps D430003I15Rik, anticorps RmP, anticorps abcr, anticorps ffm, anticorps rmp, anticorps rp19, anticorps stgd, anticorps abc10, anticorps armd2, anticorps cord3, anticorps stgd1, anticorps zgc:91823, anticorps ATP binding cassette subfamily A member 4, anticorps ATP-binding cassette, sub-family A (ABC1), member 4, anticorps ATP binding cassette subfamily A member 4 L homeolog, anticorps ATP-binding cassette, sub-family A (ABC1), member 4a, anticorps ABCA4, anticorps Abca4, anticorps abca4, anticorps abca4.L, anticorps abca4a

Sujet: ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005). Anti-ABCA4  Immunohistochemical staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Poids moléculaire: '220 kDa

ID gène: 11304

UniProt: O35600