Peripherin anticorps

N° du produit ABIN361363

Cet anticorps Souris Monoclonal détecte spécifiquement Peripherin dans WB et IF. Il présente une réactivité envers Rat.

Aperçu rapide pour Peripherin anticorps (ABIN361363)

Antigène: Peripherin (PRPH)

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Peripherin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 7C5

Détail du produit anti-Peripherin anticorps

Specificité: Specific for the ~57kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Homologie: most mammalian

Purification: Protein G purified culture supernatant

Immunogène: Recombinant rat peripherin expressed in and purified from E. coli

Isotype: IgG1

Information d'application

Indications d'application: Recommended Dilution: WB:1:1,000 IF: 1:200 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: total IgG fraction + 10 mM Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Peripherin

Antigène: Peripherin (PRPH)

Autre désignation: PRPH

Sujet: Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.

Poids moléculaire: '57 kDa

ID gène: 3414

UniProt: P21807