Vimentin anticorps

N° du produit ABIN361371

Cet anticorps anti-Vimentin est un anticorps Poulet Polyclonal détectant Vimentin dans WB et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Vimentin anticorps (ABIN361371)

Antigène: Vimentin (VIM)

Reactivité: Humain

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp Vimentin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-Vimentin anticorps

Specificité: Specific for the ~50kDa Vimentin protein. It is expected that it will work on other mammalian tissues.

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat (Rattus)

Purification: Total IgY fraction

Immunogène: Recombinant human vimentin purified from E. coli

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1,000 IF: 1:500 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-Vimentin (ABIN361371)

Kirane, Toombs, Larsen, Ostapoff, Meshaw, Zaknoen, Brekken, Burrows: "Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib." dans: Carcinogenesis, Vol. 33, Issue 9, pp. 1639-46, (2012) (PubMed).

Kirane, Toombs, Ostapoff, Carbon, Zaknoen, Braunfeld, Schwarz, Burrows, Brekken: "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 5031-42, (2012) (PubMed).

Détails sur Vimentin

Antigène: Vimentin (VIM)

Autre désignation: VIM

Sujet: Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006). Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons). Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008).

Poids moléculaire: '50 kDa

ID gène: 7431

UniProt: P08670

Pathways: Caspase Cascade in Apoptosis