THRA anticorps (N-Term)

N° du produit ABIN361383

Cet anticorps anti-THRA est un anticorps Souris Monoclonal détectant THRA dans WB. Adapté pour Humain.

Aperçu rapide pour THRA anticorps (N-Term) (ABIN361383)

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB)

Clone: 1718

Détail du produit anti-THRA anticorps

Épitope: N-Term

Specificité: Specific for the ~50k TR-a1 and the ~58k TR-a2 protein.

Réactivité croisée: Humain, Rat (Rattus)

Homologie: canine, mouse, non-human primate

Purification: Protein G purified culture supernatant

Immunogène: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Isotype: IgG2a

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA

Sujet: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.

Poids moléculaire: 50/58 kDa

ID gène: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development