MAPK1/2 (C-Term) anticorps

N° du produit ABIN361430

Détail du produit

Antigène: MAPK1/2

Épitope: C-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Specificité: Specific for the ~42k - 44k ERK/MAPK protein. Immunolabeling is blocked by the peptide used as antigen.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Homologie: mouse

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Référence

Erickson, Ray, Wink, Bayon, Pedapati, Shaffer, Schaefer, Lahiri: "Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism." dans: Journal of psychiatric research, Vol. 84, pp. 153-160, (2017) (PubMed).

Détail du antigène

Antigène: MAPK1/2

Sujet: Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002, Ahn, 1993, Tanoue and Nishida, 2003, Johnson and Lapadat, 2002). The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993). Anti-ERK/MAPK Western blot of rat hippocampal homogenate showing specific immunolabeling of ~42-44k ERK/MAPK protein.

Poids moléculaire: 42/44 kDa

ID gène: 116590

UniProt: P63086