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Glutamate Receptor 1 anticorps (pSer831)

GLUR1 Reactivité: Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361476
  • Antigène Voir toutes Glutamate Receptor 1 (GLUR1) Anticorps
    Glutamate Receptor 1 (GLUR1)
    Épitope
    • 17
    • 17
    • 15
    • 15
    • 13
    • 13
    • 13
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer831
    Reactivité
    • 113
    • 112
    • 94
    • 11
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 124
    • 26
    • 1
    Lapin
    Clonalité
    • 113
    • 38
    Polyclonal
    Conjugué
    • 75
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Glutamate Receptor 1 est non-conjugé
    Application
    • 103
    • 40
    • 40
    • 40
    • 38
    • 28
    • 16
    • 16
    • 13
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    Specific for the ~100k GluR1 protein phosphorylated at Ser831. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by λ-phosphatase treatment.
     Réactivité croisée
    Souris, Rat (Rattus)
    Réactivité croisée (Details)
    The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with canine, chicken, human and mouse based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
    Homologie
    canine, chicken, human
    Purification
    Antigen Affinity Purified from Pooled Serum
    Immunogène
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser831 conjugated to KLH
    Top Product
    Discover our top product GLUR1 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing
    Stock
    -20 °C
  • Mao, Wang: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." dans: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).

    Xue, Chen, He, Jin, Mao, Wang: "Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine." dans: Neuropharmacology, (2016) (PubMed).

    Pasek, Wang, Colbran: "Differential CaMKII regulation by voltage-gated calcium channels in the striatum." dans: Molecular and cellular neurosciences, Vol. 68, pp. 234-43, (2016) (PubMed).

    Mao, Xue, Jin, Wang: "Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine." dans: Journal of neurochemistry, Vol. 133, Issue 6, pp. 795-805, (2015) (PubMed).

    Mao, Hastings, Fibuch, Wang: "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice." dans: European journal of pharmacology, Vol. 738, pp. 237-44, (2014) (PubMed).

    Xue, Edwards, Mao, Guo, Jin, Fibuch, Wang: "Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration." dans: Neurochemistry international, Vol. 64, pp. 48-54, (2013) (PubMed).

    Ferrario, Loweth, Milovanovic, Wang, Wolf: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." dans: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, (2011) (PubMed).

    Jiao, Jalan-Sakrikar, Robison, Baucum, Bass, Colbran: "Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation." dans: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24806-18, (2011) (PubMed).

    Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

  • Antigène
    Glutamate Receptor 1 (GLUR1)
    Autre désignation
    GRIA1 (GLUR1 Produits)
    Synonymes
    anticorps GLUH1, anticorps GLUR1, anticorps GLURA, anticorps GluA1, anticorps HBGR1, anticorps gluR-A, anticorps 2900051M01Rik, anticorps Glr-1, anticorps Glr1, anticorps GluR-A, anticorps GluRA, anticorps Glur-1, anticorps Glur1, anticorps HIPA1, anticorps gluR-K1, anticorps GRIA1, anticorps glur1, anticorps Gria1, anticorps glur1b, anticorps gria1.2, anticorps sb:eu293, anticorps ZfGluR1a, anticorps glur1a, anticorps gria1.1, anticorps zfGRIA1[a], anticorps glutamate ionotropic receptor AMPA type subunit 1, anticorps glutamate receptor, ionotropic, AMPA1 (alpha 1), anticorps glutamate receptor, ionotropic, AMPA 1, anticorps glutamate receptor, ionotropic, AMPA 1 L homeolog, anticorps GluR1 protein, anticorps Glutamate receptor 1, anticorps glutamate receptor, ionotropic, AMPA 1b, anticorps glutamate receptor, ionotropic, AMPA 1a, anticorps GRIA1, anticorps Gria1, anticorps gria1, anticorps gria1.L, anticorps glur1, anticorps glr-1, anticorps gria1b, anticorps gria1a
    Sujet
    Affinity purified rabbit polyclonal antibody. Biological Significance: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II (McGlade-McCulloh et al., 1993; Mammen et al., 1999; Roche et al., 1996). In addition, phosphorylation of this site has been linked to synaptic plasticity as well s learning and memory (Soderling and Derkach, 2000).
    Poids moléculaire
    '100 kDa
    ID gène
    50592
    NCBI Accession
    NP_113796
    UniProt
    P19490
    Pathways
    Signalisation PI3K-Akt
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