PAK1/2/3 anticorps (AA 421-425)

N° du produit ABIN362788

Détail du produit anti-PAK1/2/3 anticorps

Antigène: PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))

Épitope: AA 421-425

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK1/2/3 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Specificité: The antibody detects endogenous level of total PAK1/PAK2/PAK3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogène: Peptide sequence around AA 421-425, 400-404, 419-423 (R-S-T-M-V) derived from Human PAK1, PAK2, PAK3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur PAK1/2/3

Antigène: PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))

Autre désignation: PAK1/PAK2/PAK3 (PAK1/2/3 Produits)

Synonymes: anticorps X-PAK1, anticorps XPak1, anticorps pak, anticorps pak-1, anticorps pakalpha, anticorps p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog, anticorps p21 (RAC1) activated kinase 1, anticorps pak1.S, anticorps PAK1

Sujet: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

NCBI Accession: NP_001121, NP_002568

UniProt: O75914