Synuclein anticorps (AA 134-138)

N° du produit ABIN362982

Détail du produit anti-Synuclein anticorps

Antigène: Synuclein (SYU)

Épitope: AA 134-138

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Synuclein est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: The antibody detects endogenous level of total a-Synuclein protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogène: Peptide sequence around AA 134-138 (Q-D-Y-E-P) derived from Mouse a-Synuclein. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Références pour anticorps anti-Synuclein (ABIN362982)

Zhong, Luo, Chen, Cai, Liu, Chen, Yao: "Expression and subcellular location of alpha-synuclein during mouse-embryonic development." dans: Cellular and molecular neurobiology, Vol. 30, Issue 3, pp. 469-82, (2010) (PubMed).

Détails sur Synuclein

Antigène: Synuclein (SYU)

Autre désignation: Synuclein (SYU Produits)

Sujet: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Takahashi T,

Poids moléculaire: 18 kDa

NCBI Accession: NP_001035

UniProt: P37840