TIMP4 anticorps

N° du produit ABIN371661

Cet anticorps anti-TIMP4 est un anticorps Souris Monoclonal détectant TIMP4 dans WB, IF et IHC (fro). Adapté pour Humain.

Aperçu rapide pour TIMP4 anticorps (ABIN371661)

Antigène: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMP4 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: SB30c

Détail du produit anti-TIMP4 anticorps

Specificité: This antibody is specific to Human TIMP4.

Attributs du produit: Synonyms: TIMP-4, Tissue inhibitor of metalloproteinases 4, Metalloproteinase inhibitor 4

Purification: Purified

Immunogène: Recombinant TIMP-4.

Isotype: IgG2a

Information d'application

Indications d'application: Western Blot: Detects a band of approximately 26 kDa (predicted Mol. Weight: 26 kDa). Immunohistochemistry on Frozen Sections. Immunocytochemistry/Immunofluorescence: Use at 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TIMP4

Antigène: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Autre désignation: TIMP4

Sujet: The MMPs and TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression and a small number are produced constitutively or are expressed at very low levels and are not inducible. Among agents that induce MMP and TIMP production are the inflammatory cytokines TNF alpha and IL1 beta. A marked cell type specificity is a hallmark of both MMP and TIMP gene expression (i.e. a limited number of cell types can be induced to make these proteins). Tissue Inhibitor of Metalloproteinases 4 (TIMP4) was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 and 51 % homology with TIMP2 and TIMP3. TIMP4 is secreted extracellularly, predominantly in heart and brain tissue. It may function in a tissue specific fashion in extracellular matrix (ECM) homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth and progression. The human TIMP4 gene has the chromosomal location of 3p25.Synonyms: Metalloproteinase inhibitor 4, TIMP-4, Tissue inhibitor of metalloproteinases 4

ID gène: 7079

UniProt: Q99727