INA anticorps
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- Antigène Voir toutes INA Anticorps
- INA (Internexin Neuronal Intermediate Filament Protein, alpha (INA))
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Reactivité
- Mammifères
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp INA est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- Specific for the ~66k alpha Internexin protein.
- Réactivité croisée (Details)
- Species reactivity (tested):most Mammalian.
- Attributs du produit
- Synonyms: Alpha-Inx, INA, NEF5, NF66, 66 kDa neurofilament protein, Neurofilament-66
- Purification
- Ig Fraction
- Immunogène
- Recombinant rat alpha-Internexin expressed in and purified from E. coli.
- Clone
- ID2
- Isotype
- IgG1
- Top Product
- Discover our top product INA Anticorps primaire
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- Indications d'application
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Immunohistochemistry: 1/1,000. This antibody can be used on formalin-fixed cells in tissue culture, cryostat sections. The epitope recognized by the ID2 clone is in the C-terminal non-helical extension of theprotein and is unusually resistant to aldehyde fixation, so that this antibody is ideal forstudies of paraffin embedded formalin fixed histological sections. Western blotting: 1/2,000. Immunofluorescence: 1/250.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Stock
- -20 °C
- Stockage commentaire
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Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Date de péremption
- 12 months
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- Antigène
- INA (Internexin Neuronal Intermediate Filament Protein, alpha (INA))
- Autre désignation
- alpha-Internexin (INA Produits)
- Synonymes
- anticorps NEF5, anticorps NF-66, anticorps TXBP-1, anticorps Inexa, anticorps Intlaa, anticorps Nf66, anticorps AV028420, anticorps NF66, anticorps ina-A, anticorps xefiltin, anticorps ina-a, anticorps inexa, anticorps MGC82496, anticorps INA, anticorps si:ch211-67n3.6, anticorps nef5, anticorps xina, anticorps nf-66, anticorps txbp-1, anticorps MGC69277, anticorps gefiltin, anticorps zgc:110516, anticorps internexin neuronal intermediate filament protein alpha, anticorps internexin neuronal intermediate filament protein, alpha, anticorps internexin neuronal intermediate filament protein alpha S homeolog, anticorps low molecular weight neuronal intermediate filament S homeolog, anticorps internexin neuronal intermediate filament protein, alpha a, anticorps internexin neuronal intermediate filament protein, alpha b, anticorps INA, anticorps Ina, anticorps ina.S, anticorps nif.S, anticorps inaa, anticorps ina, anticorps inab
- Sujet
- Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits (1). Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration (2). The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder (3,4). The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals (5).Synonyms: 66 kDa neurofilament protein, Alpha-Inx, INA, NEF5, NF66, Neurofilament-66
- ID gène
- 9118
- UniProt
- Q16352
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