ABCA4 anticorps

N° du produit ABIN371821

Cet anticorps Souris Monoclonal détecte spécifiquement ABCA4 dans WB et IHC (fro). Il présente une réactivité envers Humain, Souris, Boeuf (Vache) et Xenopus laevis.

Aperçu rapide pour ABCA4 anticorps (ABIN371821)

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivité: Humain, Souris, Boeuf (Vache), Xenopus laevis

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ABCA4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3F4

Détail du produit anti-ABCA4 anticorps

Specificité: This antibody reacts with ABCA4 (Rim Protein).

Réactivité croisée (Details): Species reactivity (tested):Bovine, Human, Mouse and Xenopus.

Attributs du produit: Synonyms: ABCR, Stargardt disease protein, ATP-binding cassette sub-family A member 4,Retinal-specific ATP-binding cassette transporter

Purification: Protein G Chromatography.

Immunogène: Partially purified bovine 220-kDa disc rim protein.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry: 1/100. Western blotting: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5) 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ABCA4

Antigène: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Autre désignation: ABCA4

Sujet: ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).Synonyms: ABCR, ATP-binding cassette sub-family A member 4, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein

ID gène: 24

UniProt: P78363