THRA anticorps (N-Term)

N° du produit ABIN371843

L’anticorps anti-THRA Monoclonal Souris est utilisé pour la détection de THRA dans des échantillons de Humain, Souris, Rat et Chien. Il a été validé pour WB.

Aperçu rapide pour THRA anticorps (N-Term) (ABIN371843)

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB)

Clone: 2103

Détail du produit anti-THRA anticorps

Épitope: N-Term

Specificité: AM08268PU-N is specific for the ~50k THR alpha-1 and the ~58k THR alpha-2 proteins.

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human.

Attributs du produit: Synonyms: Thyroid hormone receptor alpha, THRA1, THRA2, C-erbA-alpha, c-erbA-1, EAR-7, EAR7,NR1A1, Nuclear receptor subfamily 1 group A member 1

Purification: Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.

Immunogène: Peptide corresponding to amino acid residues from the N-terminal region of human thyroidhormone receptor, alpha1/alpha2-isotype.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA / ERBA1

Sujet: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR-alpha1, TR-alpha2, TR-beta1 and TR-beta2. TR-alpha1, TR-beta1 and TR-beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1

ID gène: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development