XPO1 anticorps (AA 390-408)

N° du produit ABIN372248

L’anticorps Lapin Polyclonal anti-XPO1 a été validé pour WB et IHC (p). Il convient pour détecter XPO1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien et Chimpanzé.

Aperçu rapide pour XPO1 anticorps (AA 390-408) (ABIN372248)

Antigène: XPO1 (Exportin 1 (XPO1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-XPO1 anticorps

Épitope: AA 390-408

Séquence: ASPLLSGSQH FDVPPRRQL

Specificité: This antibody recognizes CRM1 Protein (XPO1).

Réactivité croisée (Details): Species reactivity (expected):Bovine, Chimpanzee, Dog, Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Synthetic peptide corresponding to the amino acids 390-408 of human Exportin-1 protein.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative and 0.2 % Gelatin as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur XPO1

Antigène: XPO1 (Exportin 1 (XPO1))

Autre désignation: XPO1 / Exportin-1

Sujet: CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli. CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT and AP-1.Synonyms: CRM1, Chromosome region maintenance 1 protein homolog, Exp1

ID gène: 7514

NCBI Accession: NP_003391

UniProt: O14980

Pathways: M Phase