GABRA1 anticorps (N-Term)

N° du produit ABIN372627

Cet anticorps anti-GABRA1 est un anticorps Lapin Polyclonal détectant GABRA1 dans WB. Adapté pour Rat, Humain, Souris, Boeuf (Vache), Chien et Non-Human Primate.

Aperçu rapide pour GABRA1 anticorps (N-Term) (ABIN372627)

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Reactivité: Rat, Humain, Souris, Boeuf (Vache), Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GABRA1 anticorps

Épitope: N-Term

Specificité: Specific for the ~51k Alpha-1 subunit of the GABAA receptor in Western blots of rat brain. Labeling is absent in Alpha-1 subunit knockout animals.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Canine and non-Human Primates.
Species reactivity (tested):Rat and Mouse.

Purification: Affinity Chromatography.

Immunogène: Peptide from the N-terminal region of the Alpha-1 subunit of rat GABAA Receptor, conjugated to keyhole limpet hemocyanin (KLH).

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur GABRA1

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Autre désignation: GABRA1

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABA A receptor subunit alpha-1, GABRA-1, Gamma-aminobutyric acid receptor subunit alpha-1

ID gène: 14394

NCBI Accession: NP_034380

UniProt: P62812