SLC6A1 anticorps (C-Term)

N° du produit ABIN372646

Cet anticorps Lapin Polyclonal détecte spécifiquement SLC6A1 dans WB et IHC (fro). Il présente une réactivité avec des échantillons de Rat et Souris.

Aperçu rapide pour SLC6A1 anticorps (C-Term) (ABIN372646)

Antigène: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC6A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SLC6A1 anticorps

Épitope: C-Term

Specificité: Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000. Immunohistochemitsry: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur SLC6A1

Antigène: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Autre désignation: GAT1 / SLC6A1

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).Synonyms: GABA transporter 1, GABATR, GABT1, GAT-1, Sodium- and chloride-dependent GABA transporter 1, Solute carrier family 6 member 1

ID gène: 79212

NCBI Accession: NP_077347

UniProt: P23978