GRM1a / GRM5 anticorps (C-Term)

N° du produit ABIN372670

Cet anticorps Lapin Polyclonal détecte spécifiquement GRM1a / GRM5 dans WB et IHC (fro). Il présente une réactivité envers Rat, Humain et Souris.

Aperçu rapide pour GRM1a / GRM5 anticorps (C-Term) (ABIN372670)

Antigène: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRM1a / GRM5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GRM1a / GRM5 anticorps

Épitope: C-Term

Réactivité croisée (Details): Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur GRM1a / GRM5

Antigène: GRM1a / GRM5 (GRM5/1a) (Glutamate Receptor, Metabotropic 5/1a (GRM5/1a))

Autre désignation: mGluR5/1a

Sujet: The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).Synonyms: GRM1A, GRM5, MGLUR1a, MGLUR5, Metabotropic Glutamate Receptor 5/1a