STXBP1 anticorps (pSer515)

N° du produit ABIN372671

L’anticorps Lapin Polyclonal anti-STXBP1 a été validé pour WB et IHC (fro). Il convient pour détecter STXBP1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Poulet et Xenopus laevis.

Aperçu rapide pour STXBP1 anticorps (pSer515) (ABIN372671)

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Poulet, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STXBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-STXBP1 anticorps

Épitope: pSer515

Specificité: This antibody recognizes ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser515 of Munc-18.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000. Immunohistochemistry: 1/400. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20°C.

Date de péremption: 12 months

Détails sur STXBP1

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Autre désignation: STXBP1 / UNC18A

Sujet: Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996).
Alternate names: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

ID gène: 25558

NCBI Accession: NP_037170

UniProt: P61765

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport