Peripherin anticorps

N° du produit ABIN372702

Cet anticorps anti-Peripherin est un anticorps Poulet Polyclonal détectant Peripherin dans WB, IF et IHC (fro). Adapté pour Rat.

Aperçu rapide pour Peripherin anticorps (ABIN372702)

Antigène: Peripherin (PRPH)

Reactivité: Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp Peripherin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Peripherin anticorps

Réactivité croisée (Details): Species reactivity (expected):many Mammalian.
Species reactivity (tested):Rat.

Purification: Ig Fraction

Immunogène: Recombinant rat peripherin expressed in and purified from E. coli.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blot: 1/1000. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur Peripherin

Antigène: Peripherin (PRPH)

Autre désignation: Peripherin

Sujet: Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.Synonyms: NEF4, PRPH, PRPH1

ID gène: 10116

UniProt: P21807