STK10-A anticorps (pSer482, pSer486, pSer490)

N° du produit ABIN372704

L’anticorps anti-STK10-A Polyclonal Lapin est utilisé pour la détection de STK10-A dans des échantillons de Humain, Souris, Rat, Poisson zèbre (Danio rerio) et Xenopus laevis. Il a été validé pour WB.

Aperçu rapide pour STK10-A anticorps (pSer482, pSer486, pSer490) (ABIN372704)

Antigène: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK10-A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-STK10-A anticorps

Épitope: pSer482, pSer486, pSer490

Specificité: This antibody recognizes the ~120k PLKK protein phosphorylated at Ser482,486,490.

Réactivité croisée (Details): Species reactivity (expected):Human, Mouse, Rat and Zebrafish.
Species reactivity (tested):Xenopus.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser482,486,490 of Xenopus polo-like kinase kinase (PLKK).

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur STK10-A

Antigène: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Autre désignation: PLKK1

Sujet: Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.Synonyms: Polo-like kinase kinase 1, stk10, xPlkk1

ID gène: 373731

NCBI Accession: NP_001079164

UniProt: Q9YHC9