TFEC anticorps (Internal Region)

N° du produit ABIN372800

L’anticorps anti-TFEC Polyclonal Chèvre est utilisé pour la détection de TFEC dans des échantillons de Souris et Rat. Il a été validé pour IHC (p) et EIA.

Aperçu rapide pour TFEC anticorps (Internal Region) (ABIN372800)

Antigène: TFEC (Transcription Factor EC (TFEC))

Reactivité: Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TFEC est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-TFEC anticorps

Épitope: Internal Region

Specificité: Recognizes Transcription Factor EC (TFEC).

Réactivité croisée (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Mouse.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide (C-HITKQQTHPERN) from an Internal region of Mouse TFEC.

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/32000. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur TFEC

Antigène: TFEC (Transcription Factor EC (TFEC))

Autre désignation: TFEC

Sujet: The DNA-binding factor TFE3 contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. TFE3 is ubiquitously expressed and can directly associates with DNA as either homodimers or heterodimers formed with two related proteins, TFEB or TFEC. TFE3 binds to and activates the microE3 motif of the immunoglobulin heavy-chain enhancer to induce B-cell-specific gene transcription and DNA recombination. TFEB binds to the major late promoter of adenovirus and specifically associates with DNA as both a homodimer and a heterodimer with TFE3. TFEB is expressed at low levels in the embryo but at high levels in the trophoblast cells of the placenta, where it plays a critical role in regulating normal vascularization of the placenta. TFEC shares a bHLH/LZ structure with TFE3 and a closely related protein microphthalmia-associated transcription factor (MITF), which is critically involved in melanocyte differentiation. Unlike TFE3, the expression of TFEC is largely restricted to fibroblasts, myoblasts, chondrosarcoma cells, and myeloma cells.Synonyms: TCFEC, TFE-C, TFEC-L, TFECL, Transcription factor EC, Transcription factor EC-like

ID gène: 21426

NCBI Accession: NP_112475

UniProt: Q9WTW4