PDE11A anticorps (Internal Region)
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- Antigène Voir toutes PDE11A Anticorps
- PDE11A (phosphodiesterase 11A (PDE11A))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat, Chien
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PDE11A est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody reacts to Phosphodiesterase 11A (PDE11A).
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human. - Purification
- Immunoaffinity Chromatography
- Immunogène
- Peptide sequence C-NSFKESMEKSSYSD, from the internal region of PDE11A
- Isotype
- IgG
- Top Product
- Discover our top product PDE11A Anticorps primaire
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- Indications d'application
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Immunohistochemistry on paraffin sections: 10 μg/mL. Western blot: 0.5 - 1.5 μg/mL. ELISA: 1/2000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Antigène
- PDE11A (phosphodiesterase 11A (PDE11A))
- Autre désignation
- PDE11A (PDE11A Produits)
- Synonymes
- anticorps PPNAD2, anticorps 6330414F14Rik, anticorps A630086N24Rik, anticorps Gm350, anticorps PDE11A1, anticorps si:ch211-222f23.5, anticorps PDE11A, anticorps ppnad2, anticorps Pde11a, anticorps phosphodiesterase 11A, anticorps phosphodiesterase 11a, anticorps dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, anticorps PDE11A, anticorps Pde11a, anticorps pde11a, anticorps LOC100470038
- Sujet
- One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP, it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.Synonyms: 5'-cyclic-AMP and -GMP phosphodiesterase 11A, Dual 3', PDE11A1, PDE11A2, PDE11A3, PDE11A4, Phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
- ID gène
- 50940
- NCBI Accession
- NP_001070664
- UniProt
- Q9HCR9
- Pathways
- cAMP Metabolic Process
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