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DRAM anticorps (C-Term)

DRAM1 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372924
  • Antigène Voir toutes DRAM (DRAM1) Anticorps
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Épitope
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 17
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 17
    Lapin
    Clonalité
    • 17
    Polyclonal
    Conjugué
    • 13
    • 2
    • 1
    • 1
    Cet anticorp DRAM est non-conjugé
    Application
    • 12
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    This antibody recognizes Damage-regulated Autophagy Modulator (DRAM).
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    Synthetic peptide - KLH conjugated corresponding to a 16 amino acids peptide from near the carboxy terminus of Human DRAM.
    Isotype
    IgG
    Top Product
    Discover our top product DRAM1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry on Frozen Sections: 2.5 μg/mL. Immunohistochemistry on Paraffin Sections: 3 μg/mL. This antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody LS-D1, followed by alkalinephosphatase-streptavidin and chromogen.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Autre désignation
    DRAM1 (DRAM1 Produits)
    Synonymes
    anticorps DRAM1, anticorps DRAM, anticorps 1200002N14Rik, anticorps Dram, anticorps dram, anticorps DNA damage regulated autophagy modulator 1, anticorps DNA-damage regulated autophagy modulator 1, anticorps DNA damage regulated autophagy modulator 1 L homeolog, anticorps DRAM1, anticorps Dram1, anticorps dram1.L
    Sujet
    Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.Synonyms: DNA damage regulated autophagy modulator protein 1, DRAM, DRAM-1, FLJ11259
    ID gène
    55332
    NCBI Accession
    NP_060840
    UniProt
    Q8N682
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