FOXC1 anticorps (C-Term)
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- Antigène Voir toutes FOXC1 Anticorps
- FOXC1 (Forkhead Box C1 (FOXC1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Poisson zèbre (Danio rerio)
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FOXC1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA)
- Séquence
- RTSGAFVYDC SKF
- Specificité
- This antibody detects FOXC1 / FKHL7 / FREAC3 at C-term.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse, Zebrafish.
- Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- Immunogène
- Peptide from C-Terminus of the protein sequence according to NP_001444.2. Genename: FOXC1
- Top Product
- Discover our top product FOXC1 Anticorps primaire
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- Indications d'application
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Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.5-1.5 μg/mL. Approx 55 kDa band observed in Human Bone Marrow lysates(calculated MW of 56.5 kDa according to NP_001444.1). Immunohistochemistry: 3 μg/mL. In paraffin embedded Human Kidney shows nuclearstaining of some cells in the glomeruli.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
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FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost." dans: Investigative ophthalmology & visual science, Vol. 59, Issue 6, pp. 2548-2554, (2019) (PubMed).
: "Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation." dans: The Journal of clinical investigation, Vol. 126, Issue 7, pp. 2437-51, (2017) (PubMed).
: "Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients." dans: Cell death & disease, Vol. 5, pp. e1069, (2014) (PubMed).
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FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost." dans: Investigative ophthalmology & visual science, Vol. 59, Issue 6, pp. 2548-2554, (2019) (PubMed).
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- Antigène
- FOXC1 (Forkhead Box C1 (FOXC1))
- Autre désignation
- FOXC1 / FKHL7 / FREAC3 (FOXC1 Produits)
- Synonymes
- anticorps ARA, anticorps FKHL7, anticorps FREAC-3, anticorps FREAC3, anticorps IGDA, anticorps IHG1, anticorps IRID1, anticorps RIEG3, anticorps FoxC1, anticorps fkhl7, anticorps freac-3, anticorps freac3, anticorps igda, anticorps ihg1, anticorps irid1, anticorps rieg3, anticorps xfd-11, anticorps ara, anticorps FOXC1, anticorps foxc1, anticorps Fkh1, anticorps Mf1, anticorps Mf4, anticorps ch, anticorps fkh-1, anticorps frkhda, anticorps CFKH-1, anticorps XFD-11, anticorps foxc1.2, anticorps id:ibd5079, anticorps forkhead box C1, anticorps forkhead box C1 S homeolog, anticorps forkhead box C1 L homeolog, anticorps Forkhead box protein C1, anticorps winged helix transcription factor XFD-11, anticorps forkhead box C1b, anticorps FOXC1, anticorps Foxc1, anticorps foxc1.S, anticorps foxc1, anticorps foxc1.L, anticorps foxc1-A, anticorps foxc1b
- Sujet
- FOXC1 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined, however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.Synonyms: FREAC-3, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3
- Poids moléculaire
- 56.8kDa (NP_001444.1).
- ID gène
- 2296
- NCBI Accession
- NP_001444
- UniProt
- Q12948
- Pathways
- Chromatin Binding, Glycosaminoglycan Metabolic Process
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