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KPNA1 anticorps (Karyopherin alpha 1 (Importin alpha 5)) (N-Term) Primary Antibody

KPNA1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc WB Hôte: Chèvre Polyclonal unconjugated
N° du produit ABIN374391
$537.90
Plus shipping costs $45.00
0.1 mg
local_shipping Destination: Etats-Unis
Available
  • Antigène
    KPNA1
    Épitope
    • 14
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 46
    • 17
    • 16
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Porc
    Hôte
    • 29
    • 9
    • 7
    • 1
    Chèvre
    Clonalité
    • 40
    • 6
    Polyclonal
    Conjugué
    • 27
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KPNA1 est non-conjugé
    Application
    • 37
    • 24
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    TTPGKENFRL KSY-C
    Specificité
    This antibody detects Importin subunit alpha-1 at N-term.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Dog Pig, Cow.
    Species reactivity (tested):Human
    Purification
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogène
    Peptide from N Terminus of the protein sequence according to NP_002255.3 Genename: KPNA1
  • Indications d'application
    Peptide ELISA: Limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 60 kDa band observed in lysates of cell lines HEK293, HeLaand HEPG2 (calculated MW of 60.0 kDa according to NP_002255.1).
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • Antigène
    KPNA1
    Autre désignation
    KPNA1 / Importin alpha-1 (KPNA1 Antibody Extrait)
    Synonymes
    IPOA5, NPI-1, RCH2, SRP1, AW494490, NPI1, Rch2, mSRP1, si:ch211-161h7.7, karyopherin subunit alpha 1, importin alpha-1 subunit, karyopherin (importin) alpha 1, karyopherin alpha 1 (importin alpha 5), KPNA1, Kpna1, EHI_124900, kpna1
    Sujet
    Protein transfer into and out of the nucleus occurs through the nuclear pore complex (NPCs). Karyopherin, a cytosolic, heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex. SRP1 (nucleoprotein interactor 1, NPI 1) is the alpha subunit of karyopherin, which acts as the receptor for the targeted protein's nuclear localization signal (Moroianu J. Crit 1997). Both subunits of karyopherin are required for protein docking at the NPC, the alpha subunit binds the substrate and the beta subunit acts as an adaptor (Moroianu J, et al. 1995). Two other proteins, p10 and the GTPase Ran, are also required for the translocation of docked proteins to the nucleus. The karyopherin dimer dissociates during import, a process mediated by RanGTP, which binds to karyopherin ß and promotes the release of both subunits from the docking site (Moroianu J. Crit 1997). The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC (Moroianu J. Crit 1997)Synonyms: IPOA5, Karyopherin alpha 1, NPI-1, Nucleoprotein interactor 1, RAG cohort protein 2, RCH2, SRP1, SRP1-beta
    ID gène
    3836
    NCBI Accession
    NP_002255
    UniProt
    P52294
    Pathways
    M Phase, Protein targeting to Nucleus
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