UNC13D anticorps (C-Term)

N° du produit ABIN374437

Détail du produit anti-UNC13D anticorps

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Épitope: C-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC13D est non-conjugé

Application: Western Blotting (WB)

Séquence: C-KQASQHALRP AP

Specificité: This antibody recognizes Munc13-4/UNC13D.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide from the the C Terminus of the protein sequence according to NP_954712.1.

Information d'application

Indications d'application: Peptide ELISA: 1/16,000. Western Blot: 1-3 μg/mL. Approx.105 kDa band observed in Human T-lymphocyte and HeLalysates (calculated MW of 125 kDa according to NP_954712.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur UNC13D

Antigène: UNC13D (Unc-13 Homolog D (UNC13D))

Autre désignation: UNC13D (UNC13D Produits)

Synonymes: anticorps FHL3, anticorps HLH3, anticorps HPLH3, anticorps Munc13-4, anticorps UNC13D, anticorps 2610108D09Rik, anticorps Jinx, anticorps mFLJ00067, anticorps Unc13h4, anticorps BIGH3, anticorps CDB1, anticorps CDG2, anticorps CDGG1, anticorps CSD, anticorps CSD1, anticorps CSD2, anticorps CSD3, anticorps EBMD, anticorps LCD1, anticorps unc-13 homolog D, anticorps unc-13 homolog D (C. elegans), anticorps transforming growth factor beta induced, anticorps UNC13D, anticorps Unc13d, anticorps TGFBI, anticorps unc13d, anticorps un13d

Sujet: Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.Synonyms: Munc13-4, Protein unc-13 homolog D

ID gène: 201294

NCBI Accession: NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process