PDE11A anticorps (Internal Region)

N° du produit ABIN374774

L’anticorps anti-PDE11A Polyclonal Chèvre est utilisé pour la détection de PDE11A dans des échantillons de Humain, Souris, Rat et Chien. Il a été validé pour WB.

Aperçu rapide pour PDE11A anticorps (Internal Region) (ABIN374774)

Antigène: PDE11A (phosphodiesterase 11A (PDE11A))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PDE11A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PDE11A anticorps

Épitope: Internal Region

Specificité: This antibody reacts to PDE11A.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-NSFKESMEKSSYSD, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/2000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PDE11A

Antigène: PDE11A (phosphodiesterase 11A (PDE11A))

Autre désignation: PDE11A

Sujet: One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP, it is sensitive to non selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis. There are several isoforms known: Isoform 1 is present in prostate, pituitary, heart and liverbut not in testis or in penis. Isoform 2 is believed to be expressed in testis and Isoform 4 in the adrenal cortex.Synonyms: 5'-cyclic-AMP and -GMP phosphodiesterase 11A, Dual 3', PDE11A1, PDE11A2, PDE11A3, PDE11A4, Phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A

ID gène: 50940

NCBI Accession: NP_001070664

UniProt: Q9HCR9

Pathways: cAMP Metabolic Process